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dc.contributor.authorElleaume, Hélène
dc.contributor.authorEstève, François
dc.contributor.authorBarth, Rolf F.
dc.contributor.authorGouget, Barbara
dc.contributor.authorGuerquin-Kern, Jean-Luc
dc.contributor.authorDi Wu, Ting
dc.contributor.authorDeman, Pierre
dc.contributor.authorAdam, Jean-François
dc.contributor.authorRousseau, Julia
dc.subjectRadiation therapyen
dc.subjectOsmotic pumpen
dc.subjectIntracerebral deliveryen
dc.titleIntracerebral delivery of 5-iodo-2'-deoxyuridine in combination with synchrotron stereotactic radiation for the therapy of the F98 glioma.en
dc.typeArticle accepté pour publication ou publié
dc.contributor.editoruniversityotherGesellschaft für Schwerionenforschung mbH (GSI) Gesellschaft für Schwerionenforschung;France
dc.contributor.editoruniversityotherLaboratoire Pierre Süe (LPS) CNRS : UMR9956 – CEA : DSM/IRAMIS;France
dc.contributor.editoruniversityotherBiophysique moléculaire INSERM : U350 – Institut Curie;France
dc.contributor.editoruniversityotherLab Microscopie Ion Institut Curie;France
dc.contributor.editoruniversityotherGrenoble Institut des Neurosciences (GIN) INSERM : U836 – CEA – Université Joseph Fourier - Grenoble I – CHU Grenoble;France
dc.contributor.editoruniversityotherSCIENCES CHIMIQUES DE RENNES CNRS : UMR6226 – Université de Rennes I – Institut National des Sciences Appliquées de Rennes – Ecole Nationale Supérieure de Chimie de Rennes;France
dc.description.abstractenIodine-enhanced synchrotron stereotactic radiotherapy takes advantage of the radiation dose-enhancement produced by high-Z elements when irradiated with mono-energetic beams of synchrotron X-rays. In this study it has been investigated whether therapeutic efficacy could be improved using a thymidine analogue, 5-iodo-2'-deoxyuridine (IUdR), as a radiosentizing agent. IUdR was administered intracerebrally over six days to F98 glioma-bearing rats using Alzet osmotic pumps, beginning seven days after tumor implantation. On the 14th day, a single 15 Gy dose of 50 keV synchrotron X-rays was delivered to the brain. Animals were followed until the time of death and the primary endpoints of this study were the mean and median survival times. The median survival times for irradiation alone, chemotherapy alone or their combination were 44, 32 and 46 days, respectively, compared with 24 days for untreated controls. Each treatment alone significantly increased the rats' survival in comparison with the untreated group. Their combination did not, however, significantly improve survival compared with that of X-irradiation alone or chemotherapy alone. Further studies are required to understand why the combination of chemoradiotherapy was no more effective than X-irradiation alone.en
dc.relation.isversionofjnlnameJournal of Synchrotron Radiation
dc.relation.isversionofjnlissuePt 4en
dc.relation.isversionofjnlpublisherInternational Union of Crystallographyen
dc.subject.ddclabelSciences connexes (physique, astrophysique)en

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