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dc.contributor.authorBousquet, Jean
HAL ID: 21213
ORCID: 0000-0002-0217-5483
dc.contributor.authorAnto, Josep M.
dc.contributor.authorSterk, Peter J.
dc.contributor.authorAdcock, Ian M.
dc.contributor.authorChung, Kian F.
dc.contributor.authorRoca, Josep
dc.contributor.authorAgusti, Alvar
dc.contributor.authorBrightling, Chris
dc.contributor.authorCambon-Thomsen, Anne
dc.contributor.authorCesario, Alfredo
dc.contributor.authorAbdelhak, Sonia
dc.contributor.authorAntonarakis, Stylianos E.
dc.contributor.authorAvignon, Antoine
HAL ID: 183483
ORCID: 0000-0003-0197-132X
dc.contributor.authorBallabio, Andrea
dc.contributor.authorBaraldi, Eugenio
dc.contributor.authorBaranov, Alexander
dc.contributor.authorBieber, Thomas
dc.contributor.authorBockaert, Joël
HAL ID: 183079
ORCID: 0000-0001-8226-9529
dc.contributor.authorBrahmachari, Samir
dc.contributor.authorBrambilla, Christian
dc.contributor.authorBringer, Jacques
dc.contributor.authorDauzat, Michel
dc.contributor.authorErnberg, Ingemar
dc.contributor.authorFabbri, Leonardo
dc.contributor.authorFroguel, Philippe
dc.contributor.authorGalas, David
dc.contributor.authorGojobori, Takashi
dc.contributor.authorHunter, Peter
dc.contributor.authorJorgensen, Christian
dc.contributor.authorKauffmann, Francine
dc.contributor.authorKourilsky, Philippe
dc.contributor.authorKowalski, Marek L.
dc.contributor.authorLancet, Doron
dc.contributor.authorLe Pen, Claude
dc.contributor.authorMallet, Jacques
dc.contributor.authorMayosi, Bongani
dc.contributor.authorMercier, Jacques
HAL ID: 19648
ORCID: 0000-0001-7583-1069
dc.contributor.authorMetspalu, Andres
dc.contributor.authorNadeau, Joseph H.
dc.contributor.authorNinot, Grégory
HAL ID: 176914
ORCID: 0000-0001-8248-9169
dc.contributor.authorNoble, Denis
dc.contributor.authorOztürk, Mehmet
dc.contributor.authorPalkonen, Susanna
dc.contributor.authorPréfaut, Christian
dc.contributor.authorRabe, Klaus
dc.contributor.authorRenard, Eric
dc.contributor.authorRoberts, Richard G.
dc.contributor.authorSamolinski, Boleslav
dc.contributor.authorSchünemann, Holger J.
dc.contributor.authorSimon, Hans-Uwe
dc.contributor.authorSoares, Marcelo B.
dc.contributor.authorSuperti-Furga, Giulio
dc.contributor.authorTegner, Jesper
dc.contributor.authorVerjovski-Almeida, Sergio
dc.contributor.authorWellstead, Peter
dc.contributor.authorWolkenhauer, Olaf
dc.contributor.authorWouters, Emiel
dc.contributor.authorBalling, Rudi
dc.contributor.authorBrookes, Anthony J.
dc.contributor.authorCharron, Dominique
dc.contributor.authorPison, Christophe
dc.contributor.authorChen, Zhu
dc.contributor.authorHood, Leroy
dc.contributor.authorAuffray, Charles
dc.date.accessioned2011-09-14T07:25:15Z
dc.date.available2011-09-14T07:25:15Z
dc.date.issued2011
dc.identifier.urihttps://basepub.dauphine.fr/handle/123456789/6950
dc.language.isoenen
dc.subjectholistic approach to diseaseen
dc.subjecthealth systemen
dc.subject.ddc334en
dc.subject.classificationjelI12en
dc.subject.classificationjelI11en
dc.titleSystems medicine and integrated care to combat chronic noncommunicable diseasesen
dc.typeArticle accepté pour publication ou publié
dc.description.abstractenWe propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.en
dc.relation.isversionofjnlnameGenome Medicine
dc.relation.isversionofjnlvol3en
dc.relation.isversionofjnlissue7en
dc.relation.isversionofjnldate2011
dc.relation.isversionofjnlpages12en
dc.relation.isversionofdoihttp://dx.doi.org/10.1186/gm259en
dc.identifier.urlsitehttp://genomemedicine.com/content/3/7/43en
dc.description.sponsorshipprivateouien
dc.relation.isversionofjnlpublisherBioMed Centralen
dc.subject.ddclabelEconomie socialeen


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