Gene Expression Profiling Identities Eleven DNA Repair Genes Down Regulated During Mouse Neural Crest Cell Migration
Coco, Simona; Truini, Mauro; Mirisola, Valentina; Falugi, Carla; Di Candia, Michele; Scaruffi, Paola; Moretti, Stefano; Brizzolara, Antonella; Albino, Domenico; Tonini, Gian Paolo (2011), Gene Expression Profiling Identities Eleven DNA Repair Genes Down Regulated During Mouse Neural Crest Cell Migration, The International Journal of Developmental Biology, 55, 1, p. 65-72. http://dx.doi.org/10.1387/ijdb.092970da
TypeArticle accepté pour publication ou publié
Journal nameThe International Journal of Developmental Biology
MetadataShow full item record
Di Candia, Michele
Tonini, Gian Paolo
Abstract (EN)Neural Crest Cells (NCCs) are a transient multipotent migratory cells that derive from embryonic neural crest structure and in turn neural crest derives from the margin of the neural tube. DNA repair genes have been shown to be expressed in the early stages of mammalian development probably to reduce possible replication errors and genotoxic damages. Several birth defects and some cancers are due to inappropriate or defective DNA repair machinery indicating that a right activity of DNA repair genes in the early stages of fetal development is essential for an appropriate DNA function. A complete profile of DNA repair genes during embryo development has not been yet assess. We performed a genome-wide gene expression analysis by high-density oligo-microarray of mouse NCCs at E8.5, at E13.3 and at P90 and we found 11 genes involved in DNA repair activity overexpressed in the early stages of mouse embryo development whereas their expression become undetectable in the adrenal medulla of adult mouse. Among the 11 genes, 6 were never been observed high expressed in mouse embryology. Our results suggest that high expression of NCCs DNA repair genes in early embryonal stages needs to maintain DNA integrity. Failure of some of these genes may be associated to both genetic and cancer diseases.
Subjects / KeywordsDNA Repair Genes; Neural Crest Cells
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