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How does variability in cells aging and growth rates influence the malthus parameter?

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OLIVIERrev2.pdf (585.6Kb)
Date
2017
Dewey
Probabilités et mathématiques appliquées
Sujet
Malthus parameter; cell division; structured populations; age-structured equation; piecewise-deterministic Markov process; continuous-time tree; size-structured equation; eigen-problem
Journal issue
Kinetic & Related Models
Volume
10
Number
2
Publication date
2017
Article pages
481-512
Publisher
American Institute of Mathematical Sciences
DOI
http://dx.doi.org/10.3934/krm.2017019
URI
https://basepub.dauphine.fr/handle/123456789/17113
Collections
  • CEREMADE : Publications
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Author
Olivier, Adélaïde
Type
Article accepté pour publication ou publié
Abstract (EN)
The aim of this study is to compare the growth speed of different populations of cells measured by their Malthus parameter. We focus on both the age-structured and size-structured equations. A first population (of reference) is composed of cells all aging or growing at the same rate v¯. A second population (with variability) is composed of cells each aging or growing at a rate v drawn according to a non-degenerated distribution ρ with mean v¯. In a first part, analytical answers are provided for the age-structured model. In a second part, numerical answers based on stochastic simulations are derived for the size-structured model. It appears numerically that for experimentally plausible division rates the population with variability proliferates more slowly than the population of reference. The decrease in the Malthus parameter we measure, around 2% for distributions ρ with realistic coefficients of variations around 15-20%, is determinant since it controls the exponential growth of the whole population.

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