Separation of traveling waves in cortical networks using optical imaging

Schmidt, Nicolas; Peyré, Gabriel; Fregnac, Yves; Roland, Per

Schmidt, Nicolas; Peyré, Gabriel; Fregnac, Yves; Roland, Per (2010), Separation of traveling waves in cortical networks using optical imaging, 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, IEEE : Piscataway, NJ, p. 868-871. 10.1109/ISBI.2010.5490124

Type

Communication / Conférence

External document link

https://hal.archives-ouvertes.fr/hal-00450733

Date

2010

Conference title

7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

Conference date

2010-04

Conference city

Rotterdam

Conference country

Netherlands

Book title

2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

Publisher

IEEE

Published in

Piscataway, NJ

ISBN

978-1-4244-4125-9

Pages

868-871

Abstract (EN)

This paper introduces a mathematical model of the spatio-temporal patterns of visually evoked activity observed using Voltage-Sensitive Dye Imaging (VSDI) of the visual cortex. The cortical activity is described using a linear superposition of waves traveling with different speeds. This model improves the quality of the wave detection and still respects the previous approaches, as it integrates several biologically plausible constraints: 1) separability of the sources in terms of cortical location; 2) separability of the waves in terms of propagation speed, and 3) additivity of the depolarizing effects of the waves. Under these assumptions, a traveling component analysis algorithm performs a full separation of the set of waves and recovers the locations of the neural sources. Both features could help to better understand the dynamics of evoked activity in cortical sensory networks.

Subjects / Keywords

Signal reconstruction; Optical imaging; Inverse problems; Propagation; Partial differential equations