Potential Budgetary Impact of Large Scale Screening of Small Fiber Neuropathy in the Follow-Up of Patients with Type 2 Diabetes in France
Lévy, Pierre; Bordier, Lyse; Calvet, Jean-Henri; Le Hérissé, Gaëlle; Bauduceau, Bernard (2015), Potential Budgetary Impact of Large Scale Screening of Small Fiber Neuropathy in the Follow-Up of Patients with Type 2 Diabetes in France, Journal of Diabetes & Metabolism, 6, 10. 10.4172/2155-6156.1000618
TypeArticle accepté pour publication ou publié
Journal nameJournal of Diabetes & Metabolism
MetadataShow full item record
Laboratoire d'Economie de Dauphine [LEDa]
Hôpital d'Instruction des Armées Begin
Le Hérissé, Gaëlle
Hôpital d'Instruction des Armées Begin
Abstract (EN)Aims: The burden of diabetes-related complications is important and increasing in France. Early screening of microvascular complications could avoid the occurrence of more severe consequences. An economic model using a 5-year time horizon was developed to estimate the potential impact in France of large screening of diabetic autonomic neuropathy using Sudoscan, a quick, non-invasive and quantitative method developed for screening of small fiber neuropathy. Methods: A disease progression model was first developed to describe the long-term evolution of patients with type 2 diabetes regarding microvascular complications over successive time periods and patients were classified in 4 groups according to the severity. Complication-related costs were then calculated for a cohort of patients treated according to the current pattern of care and compared with the costs incurred by the same cohort assuming the introduction and widespread use of a large screening of small fiber neuropathy using the Sudoscan method. Comparison of treatment costs between the two situations was used to evaluate the potential budget impact of such a prevention policy in France. Results: According to this general screening of early complications more than 25,000 patients could avoid more severe complications. The gross benefit of such a new prevention strategy would be around € 280 million at 5th year. After 5 years of follow-up, the cumulated gross benefit would be € 837 million and in the worst case scenario (decrease of 20% for each uncertain parameter, namely the distribution of patients among severity groups, the death rates in each severity group, and the distribution of newly diagnosed patients in each severity group) gross benefit would remain at more than € 50 million for the first year and more than € 255 million at the 5th year (using 6% as global efficacy of screening method as basal value). Conclusion: Large screening of small fiber neuropathy could avoid more severe peripheral neuropathy and consequently decrease the burden related to such complications for a limited investment.
Subjects / KeywordsMicrovascular complications; Diabetic autonomicneuropathy; Sudomotor function; Prevention program
Showing items related by title and author.
FINE-CKD Model to Evaluate Economic Value of Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes Pochopień, M. T.; Cherney, D. Z. I.; Folkerts, K.; Lévy, Pierre; Millier, Aurélie; Morris, S.; Roy-Chaudhury, P.; Sullivan, S. D.; Mernagh, P. (2021) Article accepté pour publication ou publié
Impact of methodological choices on a meta-analysis of real-world evidence comparing non-vitamin K antagonist oral anticoagulants with vitamin K antagonists for the treatment of patients with non-valvular atrial fibrillation Briere, Jean-Baptiste; Wu, Olivia; Bowrin, Kevin; Millier, Aurélie; Toumi, Mondher; Taieb, Vanessa; Lévy, Pierre; Coleman, Craig I. (2019) Article accepté pour publication ou publié
Design and rationale of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study De Caterina, Raffaele; Kelly, Peter; Monteiro, Pedro; Deharo, Jean Claude; de Asmundis, Carlo; López-de-Sá, Esteban; Weiss, Thomas W.; Waltenberger, Johannes; Steffel, Jan; de Groot, Joris R.; Lévy, Pierre; Bakhai, Ameet; Zierhut, Wolfgang; Laeis, Petra; Reimitz, Paul-Egbert; Kirchhof, Paulus (2019) Article accepté pour publication ou publié
Estimation of the costs attributable to vitamin K antagonist treatment in patients with non-valvular atrial fibrillation from a French societal perspective Lévy, Pierre; Smadja, David M.; Dorey, Julie; Toumi, Mondher; Meinecke, Anna-Katharina; Bowrin, Kevin; Briere, Jean-Baptiste (2019) Article accepté pour publication ou publié